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September 5, 2025Annual Review of Physiology

Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure

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Authors

RMRachel Q MuirJXJiaojiao XuAMAlexandra D. Medcalf

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Overview

This review discusses sex differences in blood pressure in both males and females, highlighting GPER and the microbiome's impact on regulation.

Key Points

  • Females generally exhibit lower blood pressure than males before menopause, impacting hypertension management.
  • Key factors influencing blood pressure include the renin-angiotensin-aldosterone system, microbiome, and immune cells.
  • This review integrates insights from cardiovascular function and novel findings related to GPER and Klotho.
  • Understanding these sex differences can guide future research and improve clinical approaches to treating hypertension.

Cite This Study

Muir et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d64780d98https://doi.org/10.1146/annurev-physiol-050724-022450
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