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September 5, 2025ACS OmegaOpen Access

Study on Antitumor Secondary Metabolites from Euphorbia ebracteolata Hayata: Structural Characterization, Network Pharmacology, Molecular Docking and In Vitro

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Authors

NXNong XuYYYonghui YangLDLan Ding

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Overview

Chemical investigation reveals secondary metabolites with antitumor activity in tumor cell lines, indicating valuable therapeutic potential.

Key Points

  • Euphebranone A showed significant antiproliferation activity against SMMC-7721 cells, supporting its antitumor potential.
  • The study identified 21 secondary metabolites, with five new compounds named euphebranones A–E distinguished through structural analysis.
  • Mechanistic studies reveal that (±)-euphebranone A induces cell-cycle arrest and impacts key cancer signaling pathways.
  • Utilizing network pharmacology and molecular docking, the research highlights new avenues for cancer treatment using natural products.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d64780221https://doi.org/10.1021/acsomega.5c04875
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