September 5, 2025Saudi Medical JournalOpen Access

Serum levels of GDF-15, betatrophin, TNF-α and IL-6 in diabetic patients with and without diabetic complications

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GDF-15 levels were significantly higher in diabetic patients compared to healthy controls, highlighting its potential as a biomarker.
Diabetic patients with complications had the highest median GDF-15 concentrations, suggesting a link to disease severity.
TNF-α, IL-6, and betatrophin also showed significantly increased levels in diabetics relative to controls.
Findings indicate that monitoring GDF-15 may help assess the risk of complications in diabetes patients.

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Cross-sectional analysis reveals elevated GDF-15 and inflammatory markers in diabetic patients, indicating severer conditions.

Yılmaz et al. (2025) studied this question.

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