September 5, 2025Cancer Drug ResistanceOpen Access

Targeting the hypoxia signaling pathway with nanomedicine to reverse immunotherapy resistance

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Discussion

Review reveals hypoxia's role in immunotherapy resistance and highlights nanotechnology strategies for overcoming it.

Hypoxia influences immunotherapy resistance by promoting macrophage polarization and inducing T cell exhaustion.
Nanomedicine strategies may counteract hypoxia-induced resistance, potentially transforming cancer treatment approaches.
The review outlines challenges of applying advanced drug delivery systems in clinical contexts related to immunotherapy.
Targeting the hypoxia signaling pathway could enhance the efficacy of immunotherapy in resistant cancer cases.

Cheng et al. (2025) studied this question.

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