September 5, 2025Health Science ReportsOpen Access

Assessment of rs1205 and rs1130864 Polymorphisms of C‐Reactive Protein Gene (CRP) and Serum CRP Levels in Immune Thrombocytopenia: A Case‐Control Study

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Serum CRP levels were significantly higher in ITP patients compared to controls, indicating a strong inflammatory response.
Higher CRP levels showed 80.4% sensitivity and 100% specificity at a 7.55 mg/L cut-off, making it a potential diagnostic marker.
No significant association was found between rs1205 and rs1130864 polymorphisms and ITP susceptibility or disease outcomes.
Results highlight the need for further research into the inflammatory mechanisms involved in immune thrombocytopenia.

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Case-control analysis evaluates serum CRP levels and polymorphisms in ITP patients, suggesting inflammatory involvement.

Sarbazjoda et al. (2025) studied this question.

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