September 5, 2025Frontiers in ImmunologyOpen Access

Characteristics of the tumor microenvironment and potential immunotherapy strategies in renal cell carcinoma

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Review explores tumor microenvironment and immunotherapy in renal cell carcinoma, suggesting new biomarker-guided approaches.

Understanding the tumor microenvironment is crucial for improving immunotherapy responses in renal cell carcinoma.
Emerging biomarkers like PD-L1 and tumor mutational burden may help predict responses to immune checkpoint inhibitors.
Combination therapies have shown promise in renal cell carcinoma treatment, but challenges like toxicity remain.
Future research should target tumor microenvironment heterogeneity to enhance precision immunotherapy strategies.

Wen et al. (2025) studied this question.

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