September 5, 2025Food Science & NutritionOpen Access

Black Cumin Seed (Nigella sativa) Confers Anti‐Adipogenic Effects in 3T3‐L1 Cellular Model and Lipid‐Lowering Properties in Human Subjects

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Black cumin seed significantly reduced triglycerides and LDL cholesterol in participants consuming the extract.
The study found a marked downregulation of key adipogenic transcription factors after treatment in 3T3-L1 cells.
High phenolic and flavonoid contents were confirmed through analyses, providing a rich phytochemical profile.
No cytotoxicity was observed in 3T3-L1 cells treated with black cumin seed extract, supporting its safety.

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RCT demonstrates significant lipid reduction in human subjects, while anti-adipogenic effects observed in 3T3-L1 cells.

Ahmed et al. (2025) studied this question.

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