September 5, 2025Separation Science Plus

Bioanalytical Method Development and Validation of Tofacitinib in Rat Plasma Using Green Solvent and Application to Pharmacokinetic Study by LC‐MS

View Full Paper

Ask AI

Bookmark

Authors

VJVipul Joshi VVVipul Vaghela PGPoonam Giri

Discussion

Member takes

Implication

Bioanalytical method develops eco-friendly processing of tofacitinib in rat plasma, suggesting greener practices. The method adheres to ICH M10 guidelines and offers reliable pharmacokinetic insights.

Key Points

The method developed shows good linearity for tofacitinib detection from 1–1000 ng/mL using LC-MS.
Validation results indicate acceptable precision with intra-day variability between 2.17% and 12.34%.
The use of methanol instead of acetonitrile aligns with green chemistry principles for drug analysis.
Pharmacokinetic studies in rats illustrate the practical application of this validated method.

Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f07f https://doi.org/10.1002/sscp.70112

View Full Paper

Ask AI

Bookmark

Bioanalytical Method Development and Validation of Tofacitinib in Rat Plasma Using Green Solvent and Application to Pharmacokinetic Study by LC‐MS

Discussion

Member takes

Implication

Key Points

Cite This Study

Bioanalytical Method Development and Validation of Tofacitinib in Rat Plasma Using Green Solvent and Application to Pharmacokinetic Study by LC‐MS

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider