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September 5, 2025Journal of ObesityOpen Access

MRI‐Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites

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Authors

AAAltayeb AhmedMCMadeleine CuleANAfreen Naz

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Overview

Analysis of MRI data reveals associations between fat distribution and type 2 diabetes, suggesting depot-specific health implications.

Key Points

  • Genetically higher abdominal subcutaneous adipose tissue is linked to an adverse metabolic profile and increased risk of type 2 diabetes.
  • The study identified distinct genetic loci related to 10 different fat depots, significantly highlighting differences in disease risks.
  • Using MRI data from the UK Biobank, the analysis involved 37,589 participants and assessed various health outcomes.
  • Higher thigh subcutaneous adipose tissue was associated with lower risks of type 2 diabetes and improved cardiovascular outcomes.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477edafhttps://doi.org/10.1155/jobe/7792701
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