Functions and Mechanisms of Diabetes-Linked Transcription Factors

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Discussion

Review highlights transcription factors' involvement in insulin secretion and glucose metabolism, suggesting therapeutic avenues.

Dysregulation of transcription factors is linked to type 1 and type 2 diabetes pathogenesis, impacting insulin secretion.
Transcription factors regulate gene expression through binding, DNA methylation, and post-transcriptional mechanisms.
Recent findings indicate transcription factors play a central role in pancreatic beta cell failure amid insulin resistance.
Therapeutic modulation may normalize pancreatic beta cell function, though challenges in targeted delivery and safety remain.

Parthiban et al. (2025) studied this question.

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