September 5, 2025Open Access

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by ageing

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Authors

ICIrene Calvo‐AsensioUniversity of Basel ATAndreas TarcevskiUniversity of Basel FDFatima DhallaUniversity of Oxford

Discussion

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Implication

Observational analysis reveals that ageing preferentially impacts Ly6d- thymic epithelial progenitor cells, suggesting connections to thymic function.

Key Points

Ageing disproportionately affects Ly6d- thymic epithelial progenitor cells compared to Ly6d+ cells, indicating a complex response to age.
Two lineage-biased thymic epithelial progenitor populations were identified through analysis of Ly6d expression and lineage tracing.
Single-cell RNA sequencing technology uncovered significant heterogeneity in thymic epithelial cells, revealing their potential roles in thymic maintenance.
Our findings provide insights into the dynamic relationships between thymic epithelial progenitors and their differentiation in the context of ageing.

Cite This Study

Calvo‐Asensio et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477eb85 https://doi.org/10.1101/2025.08.28.672880

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Implication

Observational analysis reveals that ageing preferentially impacts Ly6d- thymic epithelial progenitor cells, suggesting connections to thymic function.