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September 5, 2025International Journal of Applied PharmaceuticsOpen Access

Design and Characterization of Optimized Polyherbal Nanoencapsulation: In Vitro Antioxidant Activity Targeting Nrf2 and GST Pathways

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Authors

RCRafiastiana CapritasariASArif Budi SetiantoAAAkrom Akrom

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Overview

In vitro analysis reveals enhanced antioxidant activity in polyherbal nanoencapsulation, suggesting potential for effective drug delivery.

Key Points

  • The optimized nanoencapsulation shows a particle size of 115.463 nm, facilitating better solubility and delivery.
  • Higher Nrf2 expression values were observed in polyherbal preparations at 3% and 1% concentrations compared to controls.
  • Nanoencapsulation was achieved using chitosan and sodium tripolyphosphate to improve bioavailability of the herbal extracts.
  • Enhancement of antioxidant activity through Nrf2 and GST regulation indicates potential therapeutic applications.

Cite This Study

Capritasari et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e6c9https://doi.org/10.22159/ijap.2025.v17s3.07
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