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September 5, 2025Nature CommunicationsOpen Access

CLADES: a hybrid NeuralODE-Gillespie approach for unveiling clonal cell fate and differentiation dynamics

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Authors

MGMingze GaoMBMelania BarileSCShirom Chabra

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Overview

Observational analysis estimates clonal differentiation dynamics in hematopoiesis, suggesting new insights into stem cell behavior.

Key Points

  • CLADES successfully estimates clone-specific differentiation kinetics and cell division dynamics.
  • The approach combines a NeuralODE framework with Gillespie simulations, enhancing the interpretation of lineage data.
  • CLADES allows for the grouping of individual clones into meta-clones, revealing characteristic behaviors.
  • The methodology provides new quantitative insights into hematopoietic stem and progenitor cell dynamics.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e4c6https://doi.org/10.1038/s41467-025-63150-6
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