Stem cell-based tissue engineering for the regeneration of periodontal structures: A systemic review of current progress and barriers

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Systematic review highlights stem cell therapies for tissue engineering in periodontal disease, indicating barriers to clinical translation.

Stem cell therapies show promise in regenerating periodontal tissues, but clinical translation remains limited.
Periodontal ligament stem cells (PDLSCs) demonstrate the highest regeneration potential among various stem cell types reviewed.
Research conducted from 2000 to 2025 indicates significant barriers such as immune responses affecting clinical outcomes.
Optimizing scaffold design is essential for improving the efficacy of tissue engineering approaches in periodontal regeneration.

Ghafarian et al. (2025) studied this question.

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Systematic review highlights stem cell therapies for tissue engineering in periodontal disease, indicating barriers to clinical translation.