September 5, 2025NutrientsOpen Access

Individual and Combined Effects of Medium- and Long-Chain Triacylglycerol and 2′-Fucosyllactose on Small Intestinal Morphology, Barrier Function, and Gut Microbiota in Growing C57BL/6 Mice

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MLCT intervention raised villus height and crypt depth, enhancing small intestinal morphology.
2′-FL elevated Paneth cell count and sIgA levels, indicating improved barrier function.
Combined MLCT + 2′-FL intervention increased the V/C ratio and goblet cell count.
16S rRNA sequencing revealed distinct effects on gut microbiota composition among interventions.

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Implication

Observational analysis finds combined interventions improve small intestinal morphology and gut microbiota in C57BL/6 mice, suggesting potential health benefits.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d887 https://doi.org/10.3390/nu17172837

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Implication

Observational analysis finds combined interventions improve small intestinal morphology and gut microbiota in C57BL/6 mice, suggesting potential health benefits.

Individual and Combined Effects of Medium- and Long-Chain Triacylglycerol and 2′-Fucosyllactose on Small Intestinal Morphology, Barrier Function, and Gut Microbiota in Growing C57BL/6 Mice

Key Points

Discussion

Implication

Cite This Study

Individual and Combined Effects of Medium- and Long-Chain Triacylglycerol and 2′-Fucosyllactose on Small Intestinal Morphology, Barrier Function, and Gut Microbiota in Growing C57BL/6 Mice

Key Points

Discussion

Implication

Cite This Study