September 5, 2025CancersOpen Access

High RAS Allele Frequency Signals Increased Risk of TERT Promoter Mutations in Thyroid Tumors

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Higher RAS allele frequency is associated with TERT promoter mutations and larger tumor size.
Mean RAS allele frequency was significantly higher in nodules with both RAS and TERT mutations at 38.1%.
The study involved a retrospective chart review of 111 patients with thyroid nodules harboring RAS mutations.
Higher RAS allele frequency and positive gene expression profiles were noted in nodules with coexisting TERT mutations.

Authors

CLChristine Lefebvre HGHannah Greenspoon KPKayla E. Payne

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Implication

Retrospective analysis demonstrates that high RAS allele frequency correlates with TERT mutations in thyroid cancer, suggesting more aggressive features.

Cite This Study

Lefebvre et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d880 https://doi.org/10.3390/cancers17172851

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Implication

Retrospective analysis demonstrates that high RAS allele frequency correlates with TERT mutations in thyroid cancer, suggesting more aggressive features.

High RAS Allele Frequency Signals Increased Risk of TERT Promoter Mutations in Thyroid Tumors

Key Points

Discussion

Implication

Cite This Study

High RAS Allele Frequency Signals Increased Risk of TERT Promoter Mutations in Thyroid Tumors

Key Points

Discussion

Implication

Cite This Study