September 5, 2025Translational PsychiatryOpen Access

Dissecting the heterogeneity of autism spectrum disorder with sensory behavior, brain, and epigenetic factors

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Observational analysis reveals connections between sensory behavior, brain activity, and epigenetic factors in autism spectrum disorder.

Machine learning models that integrate neuroimaging and epigenetic data improved diagnosis of autism spectrum disorder.
Key findings indicate a significant relationship between thalamo-cortical hyperconnectivity and autism spectrum disorder.
By analyzing DNA methylation of oxytocin and AVPR genes, the research highlights the role of epigenetic factors in sensory behavior.
The study involved 34 autism spectrum disorder participants and 72 controls, indicating diverse sensory processing experiences.

Cheong et al. (2025) studied this question.

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