Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Nucleosides Nucleotides & Nucleic Acids

To investigate the molecular mechanism and prognostic value of miR-551a in glioma based on bioinformatics

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJiawei LiangCZCheng ZengWLWendi Li

Discussion

Loading...

Member takes

Overview

Observational analysis reveals miR-551a's prognostic significance in glioma, highlighting its potential as a biomarker.

Key Points

  • MiR-551a serves as a predictive biomarker for gliomas, indicating unfavorable patient prognosis if low levels are present.
  • The study reported an AUC of 0.792 for miR-551a's diagnostic capability, suggesting strong predictive potential.
  • Inhibition of miR-551a lowered glioma cell proliferation, migration, and invasion, indicating its role as an oncogene.
  • CALM3 emerged as a critical regulatory target of miR-551a, suggesting a specific gene interaction in glioma progression.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d30ahttps://doi.org/10.1080/15257770.2025.2551841
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The potential role and mechanism of miR-1910-5p in the prognosis of glioma2025
  2. 2miR-21 as a Diagnostic and Prognostic Biomarker in Glioma: Tissue and Serum Expression Analysis in a Pakistani Cohort2025
  3. 3P05.17.A CIRCULATING MIRNA-21 IN PLASMA CORRELATES WITH FUNCTIONAL STATUS IN GLIOMA PATIENTS2025
  4. 4Inducer microRNAs in the glioma development: a concise review of mechanisms and insights into targeted therapy2025
  5. 5Insights into the regulatory role of the lncRNA H19 and miRNA-152 and their cross-talk with their target genes in glioblastoma2025