September 5, 2025Acta PhysiologicaOpen Access

Muscle Mitochondrial Dysfunction in COPD: Beyond Oxygen Consumption

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Discussion

Research finds lower ATP synthesis and oxidative phosphorylation efficiency in COPD patients, suggesting exercise adaptations are limited.

COPD patients exhibit significantly lower ATP synthesis rates compared to healthy individuals, impacting muscle function.
Key measures of mitochondrial function, including oxidative phosphorylation efficiency, were adversely affected in COPD patients during exercise.
Endurance training led to some mitochondrial benefits but did not fully restore maximal respiration rates in COPD, indicating limitations in adaptation.
The need for alternative interventions to support mitochondrial function in COPD highlights the complexity of skeletal muscle health in these patients.

Peñailillo et al. (2025) studied this question.

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Research finds lower ATP synthesis and oxidative phosphorylation efficiency in COPD patients, suggesting exercise adaptations are limited.