September 5, 2025Open Access

Neuroimaging of affective symptoms in Lewy body dementia: A systematic review

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Discussion

Systematic review reveals associations between affective symptoms and neuroimaging findings in LBD, indicating the need for targeted research.

Significant heterogeneity in imaging techniques and findings limits strong conclusions about affective symptoms in LBD.
Dopaminergic imaging was the most frequently used method across studies, highlighting its relevance in LBD assessment.
Some evidence connects affective symptoms with intrinsic brain networks, such as the default mode and salience networks.
Cholinergic denervation may link neuropsychiatric symptoms with cognitive decline, emphasizing the need for further targeted research.

Mullis et al. (2025) studied this question.

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Systematic review reveals associations between affective symptoms and neuroimaging findings in LBD, indicating the need for targeted research.