September 5, 2025Reproductive Biology and EndocrinologyOpen Access

Insulin resistance as a determinant of fertilization efficiency in polycystic ovary syndrome patients undergoing IVF/ICSI: a retrospective cohort study

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Insulin resistance was associated with lower fertilization and two-pronuclei rates in PCOS patients undergoing IVF/ICSI.
Patients with insulin resistance had significantly higher BMI and lower FSH levels than those without, indicating altered metabolic profiles.
Linear regression showed a pronounced negative impact of insulin resistance on the two-pronuclei rate, crucial for successful fertilization.
These findings highlight the importance of addressing insulin resistance in optimizing IVF outcomes for women with polycystic ovary syndrome.

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Implication

Retrospective cohort study shows insulin resistance affects fertilization and pregnancy outcomes in PCOS, indicating metabolic health is crucial for assisted reproduction.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d140 https://doi.org/10.1186/s12958-025-01453-5

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Implication

Retrospective cohort study shows insulin resistance affects fertilization and pregnancy outcomes in PCOS, indicating metabolic health is crucial for assisted reproduction.

Insulin resistance as a determinant of fertilization efficiency in polycystic ovary syndrome patients undergoing IVF/ICSI: a retrospective cohort study

Key Points

Discussion

Implication

Cite This Study

Insulin resistance as a determinant of fertilization efficiency in polycystic ovary syndrome patients undergoing IVF/ICSI: a retrospective cohort study

Key Points

Discussion

Implication

Cite This Study

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