September 5, 2025Open Access

Asymmetric Social Representations in the Prefrontal Cortex for Cooperative Behavior

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New paradigm reveals how mPFC influences cooperative decision-making in mice, highlighting social roles' impact.

Disruption of mPFC activity in followers impairs cooperation, altering decision-making processes.
Mice engaged in foraging showed distinct leader-follower roles correlated with learning speed and cooperation.
Calcium imaging in the mPFC revealed how leadership dynamics affect social value perception across roles.
This research opens new avenues for exploring the neural basis of social cognition and behavior.

Cheng et al. (2025) studied this question.

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