September 5, 2025Frontiers in LupusOpen Access

Sjögren's disease and systemic lupus erythematosus overlap: immunological insights and therapeutic implications

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The Sjögren's disease and systemic lupus erythematosus overlap presents unique immunological challenges, increasing disease activity and complications.
Persistent interferon pathway activation and B-cell dysregulation lead to chronic inflammation and hallmark autoantibody production.
Key factors such as genetic predisposition and aberrant immune response mechanisms contribute to the overlap's pathogenesis.
Emerging therapy strategies like interferon receptor inhibitors and BAFF-blocking antibodies may address specific immunological abnormalities.

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Implication

This review highlights the immunological features and therapeutic implications of Sjögren's disease and systemic lupus erythematosus overlap, suggesting potential treatment strategies.

Cite This Study

Fulvio et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477c7cf https://doi.org/10.3389/flupu.2025.1600768

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Implication

This review highlights the immunological features and therapeutic implications of Sjögren's disease and systemic lupus erythematosus overlap, suggesting potential treatment strategies.

Sjögren's disease and systemic lupus erythematosus overlap: immunological insights and therapeutic implications

Key Points

Discussion

Implication

Cite This Study

Sjögren's disease and systemic lupus erythematosus overlap: immunological insights and therapeutic implications

Key Points

Discussion

Implication

Cite This Study