September 5, 2025Frontiers in NutritionOpen Access

The effects of magnesium and vitamin D/E co-supplementation on inflammation markers and lipid metabolism of obese/overweight population: a systematic review and meta-analysis

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Discussion

Systematic review and meta-analysis found co-supplementation reduces inflammation markers in obese populations, indicating potential health benefits.

Co-supplementation of magnesium and vitamin D significantly reduced hs-CRP levels in obese individuals.
Meta-analysis of nine RCTs, involving 509 participants, demonstrated significant changes in inflammation markers.
Combination therapy showed notable reduction in TNF-α levels but did not significantly impact lipid metabolism indicators.
Middle-aged women with vitamin D deficiency may particularly benefit from magnesium and vitamin D co-supplementation.

Deng et al. (2025) studied this question.

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Systematic review and meta-analysis found co-supplementation reduces inflammation markers in obese populations, indicating potential health benefits.