Pharmacologic pain management strategies for reducing postoperative pain in total knee arthroplasty: a systematic review from molecular mechanisms to clinical efficiency
Systematic review evaluates analgesic strategies for postoperative pain in total knee arthroplasty, highlighting opioid consumption reductions and efficacy of NSAIDs.
Key Points
Duloxetine improved postoperative pain scores after total knee arthroplasty, but lacked clinical relevance.
NSAIDs showed an opioid-sparing effect, making them a validated treatment for managing postoperative pain.
The analysis indicates that multimodal pain management strategies are essential for improved outcomes following total knee arthroplasty.
Opioids, despite being often prescribed, did not demonstrate significant clinical benefits in reducing postoperative pain.