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September 5, 2025Discover OncologyOpen Access

Predictive value of MHC-related genes in cervical cancer: implications for immunotherapy and prognostic nomogram development

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Authors

MXMeili XiXWXiaoqing WangXXXiao Xu

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Overview

Analysis reveals predictive power of mhc-related genes in cervical cancer, suggesting important implications for immunotherapy and prognostic assessment.

Key Points

  • A five-gene signature linked to immune response and prognosis in cervical cancer was identified through bioinformatic analyses.
  • The signature validated with external datasets and confirmed key gene expressions using qRT-PCR and Western blot in clinical tissues.
  • Functional assays demonstrated that silencing CANX reduced cervical cancer cell proliferation and invasion, indicating its oncogenic role.
  • The proposed MHCRG-based signature enhances risk stratification and therapeutic decisions for patients with cervical cancer.

Cite This Study

Xi et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c36ahttps://doi.org/10.1007/s12672-025-03460-9
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Also Consider

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  1. 1Development of a Mitochondrial Permeability Transition‐Driven Necrosis‐Related Prognostic Signature in Cervical Cancer: Integrating Bulk Transcriptomic and Single‐Cell Data2025
  2. 2Identification of Bacterial Lipopolysaccharide-Related Molecular Subtypes and Development of a Four-Gene Prognostic Risk Model in Cervical Cancer.2025
  3. 3Identification and validation of ubiquitination-related genes for predicting cervical cancer outcome2025
  4. 4Classifying the tumor immune microenvironment in cervical cancer based on nuclear cytoplasmic consistent genes2025
  5. 5Development and validation of a novel risk stratification signature derived from migrasome and tumor microenvironment-related genes for molecular subtyping and improving clinical outcomes in head and neck squamous cell carcinoma2025