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September 5, 2025Bone ResearchOpen Access

The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies

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Authors

STSiyuan TanYSYujun SunSLShixun Li

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Overview

Review addresses mitochondrial dysfunction and oxidative stress in osteoarthritis, suggesting new mitochondria-targeted therapies.

Key Points

  • Mitochondrial dysfunction significantly contributes to cartilage degradation in osteoarthritis.
  • Chondrocytes show increased hypertrophy and apoptosis linked to mitochondrial oxidative stress.
  • Mitochondria-targeted therapies, like triphenylphosphonium, hold promise for treating osteoarthritis.
  • Therapeutic interventions aiming at mitochondria could be pivotal in improving outcomes for osteoarthritis patients.

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c1dahttps://doi.org/10.1038/s41413-025-00460-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis2025 · 16 citations
  2. 2Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal2025 · 15 citations
  3. 3The potential of mitochondrial transfer as the modifying therapy for osteoarthritis2025 · 5 citations
  4. 4Osteoarthritis: Mechanisms and Therapeutic Advances2025 · 41 citations
  5. 5The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications2025 · 17 citations