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September 5, 2025Open Access

TNFRSF12A Drives Triple-Negative Breast Cancer Progression via Immune Microenvironment Reprogramming and Facilitated Angiogenesis

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Authors

CJChunzhi JiangZZZhenwei ZhouGSGuang Shu

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Overview

Analysis reveals TNFRSF12A's influence on immune microenvironment and angiogenesis in TNBC, indicating potential therapeutic targets.

Key Points

  • Elevated levels of TNFRSF12A drive malignant progression in triple-negative breast cancer and correlate with poor patient outcomes.
  • Higher TNFRSF12A expression is linked to enhanced angiogenesis and immune modulation, reducing effectiveness against docetaxel treatment.
  • Molecular docking simulations confirmed the direct binding of TNFRSF12A with docetaxel, suggesting mechanisms of chemoresistance.
  • Knockdown of TNFRSF12A significantly improves T-cell cytotoxicity and reduces tumor vascularization, advancing therapeutic strategies.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c153https://doi.org/10.20944/preprints202508.2183.v1
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