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September 5, 2025AAP Grand Rounds

Cytomegalovirus Saliva Shedding in Congenitally Infected Children

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Overview

Observational analysis evaluates saliva CMV shedding duration in congenitally infected children, suggesting distinct outcomes based on symptomatic status.

Key Points

  • CMV was detected in saliva of children with congenital infection for a median duration of 20 months.
  • Among 197 children with congenital CMV, 12.2% were diagnosed with sensorineural hearing loss.
  • Saliva shedding prevalence decreased from 53% at 18 months to 9.5% at 4 years of age.
  • Those with intermittent viral shedding had a median duration of 30 months compared to 15 months for those without.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68c23966b210217d6477c14chttps://doi.org/10.1542/gr.54-3-28
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hearing Loss in Infants and Children with Asymptomatic Congenital Cytomegalovirus Infection: An Update in Diagnosis, Screening and Treatment2025
  2. 2Hearing Loss in Infants and Children with Asymptomatic Congenital Cytomegalovirus Infection: An Update in Diagnosis, Screening and Treatment2025 · 6 citations
  3. 3Urinary Cytomegalovirus Load at Birth as a Predictor of Sequelae in Congenital Cytomegalovirus Infection2025 · 3 citations
  4. 4Diagnostic Performance of Salivary PCR for the Detection of Congenital Cytomegalovirus: A Systematic Review and Meta-Analysis2025 · 2 citations
  5. 5Birth prevalence, clinical sequelae, and management of congenital cytomegalovirus infections in Australia, 1999–2023: a national prospective study2025