Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing the NF-κB p65/CD44 signaling pathway and attenuates osteoarthritis

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Laboratory analysis reveals eicosapentaenoic acid enhances chondrocyte mechanics in osteoarthritis, suggesting new therapeutic pathways.

Eicosapentaenoic acid significantly reduces inflammation-induced changes in chondrocyte mechanics, enhancing their functionality.
EPA lowers CD44 expression and inhibits the phosphorylation of NF-κB p65, reversing inflammation in chondrocytes.
Sequential techniques including RNA sequencing and atomic force microscopy were employed to measure and analyze chondrocyte mechanics.
The findings highlight the potential use of EPA injections integrated with hyaluronic acid as a treatment for osteoarthritis.

Yang et al. (2025) studied this question.

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