Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial
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Discussion
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Implication
Randomized trial revealed worsening congestion in heart failure patients, suggesting potential risks with volenrelaxin.
Key Points
- Volenrelaxin showed a significant increase in left atrial reservoir strain at the 25-mg dose, indicating improved function.
- The trial was halted early due to worsening congestion, with 332 enrolled patients showing concerning results.
- All dosages of volenrelaxin increased NT-proBNP levels, highlighting a potential deterioration in heart failure symptoms.
- Volenrelaxin was associated with a higher risk of hospitalization for heart failure compared to placebo, raising concerns.
Cite This Study
Borlaug et al. (2025) studied this question.