Validated RP-HPLC method quantifies dapagliflozin and linagliptin in antidiabetic formulations, indicating suitability for quality control.
Key Points
The RP-HPLC method successfully estimated three antidiabetic drugs in pharmaceutical formulations, affirming its practical utility.
Assay values for metformin, linagliptin, and dapagliflozin were 101.41%, 100.04%, and 99.73% w/w, respectively, demonstrating high accuracy.
Chromatographic separation utilized a Phenomenex Luna C18 column with a mobile phase of acetonitrile and phosphate buffer at a flow rate of 0.8 mL/min.
This method's validation followed ICH Q2 (R2) guidelines, suggesting reliability for routine pharmaceutical analysis.