September 5, 2025Mediterranean Journal of Hematology and Infectious DiseasesOpen Access

Predisposing Factors to Infections in Thalassemia Syndrome Patients

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Patients with thalassemia experienced a significant infection rate, particularly with Escherichia coli as the predominant pathogen.
Culture-positive infections occurred in 23.8% of patients, with higher ferritin levels and lower rates of chelation therapy reported.
Logistic regression analysis highlighted iron overload as a critical risk factor for infections and demonstrated a protective effect of combined chelation therapy.
Female thalassemia patients showed increased susceptibility to infections, and infection-related mortality rates were significantly higher among those with positive cultures.

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Implication

Retrospective analysis identifies iron overload and lack of chelation as major infection risk factors in thalassemia patients, suggesting improved management strategies.

Cite This Study

Mansory et al. (2025) studied this question.

synapsesocial.com/papers/68c23965b210217d6477b89d https://doi.org/10.4084/mjhid.2025.055

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Implication

Retrospective analysis identifies iron overload and lack of chelation as major infection risk factors in thalassemia patients, suggesting improved management strategies.

Predisposing Factors to Infections in Thalassemia Syndrome Patients

Key Points

Discussion

Implication

Cite This Study

Predisposing Factors to Infections in Thalassemia Syndrome Patients

Key Points

Discussion

Implication

Cite This Study

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