September 5, 2025BMC Oral HealthOpen Access

Lipid metabolites as biomarkers and therapeutic targets in oral squamous cell carcinoma

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Discussion

Exploratory analysis identifies lipid biomarkers and therapeutic targets in patients with OSCC, suggesting advancements in diagnosis and treatment.

Differential lipid metabolites were observed, with nine achieving an AUC > 0.95, indicating high potential as biomarkers.
A diagnostic model based on 10 differentiated lipids showed accuracy rates of 98.2% in training and 95.7% in validation cohorts.
Enhanced migration and invasion of OSCC cells were linked to overexpression of DGKG, marking it as a potential therapeutic target.
Lipid metabolic alterations significantly influence oral squamous cell carcinoma, emphasizing innovative diagnostic and therapeutic avenues.

Ma et al. (2025) studied this question.

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Exploratory analysis identifies lipid biomarkers and therapeutic targets in patients with OSCC, suggesting advancements in diagnosis and treatment.