September 5, 2025Frontiers in MedicineOpen Access

The dual role of vitamin C in cancer: from antioxidant prevention to prooxidant therapeutic applications

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Discussion

This review shows vitamin C's dual role in cancer, highlighting its immunomodulatory effects and implications for therapy.

Vitamin C facilitates the selective killing of tumor cells through prooxidant mechanisms, causing DNA damage and ATP depletion.
High-dose vitamin C shows synergistic effects with conventional therapies, including radio-sensitization of tumors.
Preclinical studies indicate vitamin C reprograms the tumor microenvironment, enhancing T cell infiltration and suppressing Tregs.
Translational challenges remain, including varied responses across tumor types and pharmacokinetic differences between oral and intravenous forms.

Cao et al. (2025) studied this question.

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