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September 5, 2025Frontiers in ImmunologyOpen Access

Dissecting the immune evasion and therapeutic resistance mechanisms in EGFR/TP53 co-mutated non-small cell lung cancer: implications for targeted and immunotherapy strategies

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Authors

HSHaiyan ShiKXKun XuXKXueying Kong

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Overview

Study identifies immune evasion mechanisms and therapeutic resistance in EGFR/TP53 co-mutated NSCLC, indicating new intervention strategies.

Key Points

  • Found two cancer cell populations in NSCLC, showing distinct roles in therapeutic resistance and immune evasion.
  • Detailed the connection between immune suppression in EGFR/TP53 co-mutated tumors and CD8+ T cell exhaustion through key signaling pathways.
  • Used single-cell RNA sequencing on tumor samples from 40 NSCLC patients to reveal underlying molecular mechanisms.
  • Highlights potential for targeting the STAT1/ETS1 axis along with current therapies to improve treatment outcomes.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477ac10https://doi.org/10.3389/fimmu.2025.1652213
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of CD8+ T Cell antitumor responses by EGFR-TKI in non-small cell lung cancer 29262025
  2. 2Genomic Insights into Innate Resistance in Early-Stage <i>EGFR</i>-Mutant Non-Small Cell Lung Cancer: A Comprehensive Analysis of Next-Generation Sequencing Data2025
  3. 3Evaluation of PD-L1 Expression and Anti-EGFR Therapy in EGFR-Mutant Non-Small-Cell Lung Cancer2025
  4. 4Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of <i>KEAP1</i>, <i>SMARCA4</i>, and <i>PTEN</i> mutations2025
  5. 5Transcriptomic Signatures in TP53 Positive and Negative Tumor Samples in NSCLC2025 · 6 citations