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September 5, 2025Journal of Pharmacy & Pharmaceutical SciencesOpen Access

A systematic review of real-world evidence on the clinical relevance, characterization, and utility of CYP2D6 biomarker testing

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Authors

PRP. Alcaraz RodríguezEKEmma KikerkovNENora Emmott

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Overview

This review examines the clinical relevance of cyp2d6 testing in real-world settings, highlighting barriers and facilitators.

Key Points

  • CYP2D6 biomarker testing shows measurable changes in symptoms and health outcomes, indicating its clinical relevance.
  • Nine drug-gene pairs associated with CYP2D6 met the Clinical Pharmacogenetics Implementation Consortium's criteria for strong evidence.
  • Real-world evidence from EHRs and claims data reveals challenges in PGx testing implementation and phenotype categorization.
  • Four therapeutic areas showed varying research focus on CYP2D6, with analgesia being the most studied among them.

Cite This Study

Rodríguez et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477aa7dhttps://doi.org/10.3389/jpps.2025.14708
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