Exploring the therapeutic potential of scorpion venom to mitigate colorectal cancer biomarkers in rats

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Observational analysis reveals that scorpion venom reduces cancer biomarkers in rats, suggesting potential alternative therapies.

Scorpion venom treatment significantly reduces tumor biomarkers in a rat model of colorectal cancer.
Treatment with Leiurus quinquestriatus and Androctonus bicolor venom led to a decrease in aberrant crypt foci and mucin-depleted foci.
Histopathological examination showed enhanced goblet cells and downregulation of cyclin D1 and PCNA in treatment groups.
Findings indicate that scorpion venom may offer new avenues for colorectal cancer therapy through its anti-cancer properties.

Salama et al. (2025) studied this question.

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