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September 5, 2025Exploration of Targeted Anti-tumor TherapyOpen Access

Genetic and epigenetic landscape of O6-methylguanine-DNA methyltransferase (MGMT): implications for DNA repair and cancer therapeutics

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Authors

SSShishir SinghRNRajeev NemaMBMonisha Banerjee

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Overview

This review reveals MGMT’s role in DNA repair and treatment resistance in cancer, highlighting epigenetic implications.

Key Points

  • MGMT modulation significantly impacts cancer progression and treatment resistance across malignancies.
  • Epigenetic silencing or promoter methylation of MGMT correlates with poor outcomes and therapy resistance.
  • Multi-omics approaches unveil complex regulatory layers that influence MGMT activity and therapeutic responses.
  • Innovative strategies, including CRISPR and liquid biopsies, enhance personalized cancer treatments targeting MGMT.

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a712https://doi.org/10.37349/etat.2025.1002335
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel Strategies for Improved Treatment of O6-Methylguanine-DNA Methyltransferase Promoter-Methylated Glioma2025
  2. 2MGMT-silencing as a novel biomarker in AML: Rational application of a dual alkylator-DNA crosslinker for targeted therapy2025
  3. 3High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties2025
  4. 4Data from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma2025
  5. 5P05.16.B DEFINING THE OPTIMAL MGMT METHYLATION CUTOFF AND ITS CORRELATION WITH SIGNIFICANT GENETIC ALTERATIONS2025