September 5, 2025Frontiers in ImmunologyOpen Access

Temporal dynamics of early inflammatory markers after professional dental cleaning: a meta-analysis and spline-based meta-regression of TNF-α, IL-1β, IL-6, and (hs)CRP

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Intensive nonsurgical-periodontal-therapy significantly reduces TNF-α and IL-6, indicating anti-inflammatory benefits.
With 216 observations, TNF-α saw a mean reduction of –0.59, while IL-6 dropped by –0.20 after intensive therapy.
Meta-regression revealed early benefits in inflammatory markers like TNF-α within 3 months and IL-1β within 6 months.
Although rebound in inflammatory markers is suggested, intensive therapy appears to reduce systemic inflammation, highlighting its importance.

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Meta-analysis reveals intensive nonsurgical-periodontal-therapy reduces TNF-α and IL-6 in patients, suggesting systemic benefits.

Cardisciani et al. (2025) studied this question.

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