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September 5, 2025Scientific ReportsOpen Access

Breakthrough hepatitis B virus infection and its associated factors among vaccinated children in Northwest Ethiopia

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Authors

MGMekuanint GetaAHAsrat HailuYWYimtubezinash Woldeamanuel

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Overview

Cross-sectional analysis reveals a 2.5% prevalence of breakthrough HBV infection in vaccinated children, suggesting significant public health implications.

Key Points

  • Breakthrough hepatitis B virus infection prevalence among vaccinated children was found to be 2.5%, raising public health concerns.
  • Children aged 5–9 years and 10–14 years were significantly more likely to have breakthrough HBV infection, with odds ratios of 10.7 and 20.7, respectively.
  • The study utilized logistic regression analyses to identify predictors of breakthrough infection among 325 vaccinated children in northwest Ethiopia.
  • These findings highlight the importance of monitoring vaccination effectiveness and implementing targeted prevention strategies to reduce HBV transmission.

Cite This Study

Geta et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a2cdhttps://doi.org/10.1038/s41598-025-02906-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and Factors Associated With Hepatitis B Virus Infection in Tigray Region, Northern Ethiopia2025 · 1 citations
  2. 2Serological profile of Hepatitis B virus infection among children under five years of age followed at the mother and Child University Hospital (CHU-ME) of N'Djamena, Chad2025
  3. 3Serological profile of Hepatitis B virus infection among children under five years of age followed at the mother and Child University Hospital (CHU-ME) of N'Djamena, Chad2025
  4. 4Prevalence and factors associated with Hepatitis B infection in the general population: a cross-sectional study in Moshi municipality, North-Eastern Tanzania2025
  5. 5Increased neonatal vaccine dose or booster immunization prevents hepatitis B vaccine breakthrough infection in children from HBsAg and HBeAg positive mothers2025