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September 5, 2025Anti-Cancer Agents in Medicinal Chemistry

Ursolic Acid Inhibits Triple-Negative Breast Cancer Progression by Modulating the FGFR1/AKT/ERK Pathway: Evidence from Network Pharmacology and Experimental Validation

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Authors

ZCZiming ChenWGWeiqiang GuoYGYahan Gao

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Overview

Experimental validation demonstrates ursolic acid reduces cell viability and induces apoptosis in TNBC, implicating FGFR1.

Key Points

  • Ursolic acid inhibited progression of triple-negative breast cancer by directly targeting FGFR1.
  • Cell viability decreased significantly, while apoptosis was induced in TNBC cells after ursolic acid treatment.
  • Network pharmacology indicated that ursolic acid modulates the FGFR1/AKT/ERK pathway to exert its effects.
  • Experimental methods such as western blot and xenograft models corroborated the findings on mechanistic targets of ursolic acid.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a2c4https://doi.org/10.2174/0118715206379579250722053647
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