September 5, 2025Open Access

Aberrantly expressed long noncoding RNAs in adipose-derived mesenchymal stem cells differentiation to nucleus pulposus-like cells

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Discussion

Study reveals 14 lncRNAs and 601 mRNAs in hADSCs differentiation to nucleus pulposus-like cells, indicating novel pathways involved.

Differentially expressed lncRNAs and mRNAs were identified during hADSCs differentiation into nucleus pulposus-like cells.
A total of 14 lncRNAs and 601 mRNAs were significantly identified, confirming the differentiation efficacy of hADSCs.
RNA-seq analysis and real-time PCR validated the expression levels of key genes and revealed important signaling pathways.
The findings enhance understanding of stem cell therapy for intervertebral disc degeneration and its regenerative mechanisms.

Zhu et al. (2025) studied this question.

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