Polyherbal gel formulation with Solanum nigrum , aloevera , Psidium guajava and Moringa oleifera : A preclinical evaluation for accelerated wound healing in diabetic foot ulcers
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Key Points
PGF 4 achieved an 86.04% wound closure rate, significantly enhancing healing in diabetic rats compared to standard treatments.
The α-amylase inhibitory activity of PGF 4 was notably high, reaching an IC50 of 0.093 mg/mL in cell-based assays.
In-vivo assessments showed PGF 4 significantly promoted caudal fin regeneration in zebrafish, confirming its efficacy beyond skin wounds.
Overall, findings indicate PGF 4 as a promising candidate for advanced therapeutic approaches to manage diabetic foot ulcers.
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Implication
Preclinical evaluation demonstrates significant wound healing effects in diabetic foot ulcers, suggesting potential new treatment strategies.