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September 5, 2025European Journal of Preventive CardiologyOpen Access

Peripheral vs. Central Arterial Stiffness and Cardiovascular Events in Older Adults: The Atherosclerosis Risk in Communities (ARIC) study

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Authors

TSTatsuhiro ShibataYMYejin MokSBShoshana H. Ballew

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Overview

Observational analysis reveals distinct associations of peripheral and central arterial stiffness with cardiovascular disease in older adults, suggesting cf-fa ratio as a valuable risk assessment tool.

Key Points

  • faPWV showed an inverse association with CVD, indicating a lower risk, while cfPWV was positively associated with increased CVD events.
  • During a median 9.0-year follow-up, 607 CVD events were recorded, with the cf-fa ratio demonstrating a stronger association with CVD risk than cfPWV alone.
  • The primary outcome was cardiovascular disease, emphasizing the significance of assessing both peripheral and central arterial stiffness in clinical settings.
  • The findings support the cf-fa ratio as a potential alternative measure for evaluating cardiovascular risk factors in older adults.

Cite This Study

Shibata et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64779231https://doi.org/10.1093/eurjpc/zwaf545
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