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September 5, 2025Asian Journal of Pharmaceutical Research and Health CareOpen Access

Antibacterial Efficacy of 0.5% Aqueous Piper betle Leaf Extract and 0.2% Chlorhexidine as Mouth Rinse in High Caries Risk Population – An In vitro and an In vivo Real-time Polymerase Chain Reaction Study

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Authors

AJAlexander W. JustinKRKothandaraman RajkumarLALourdusamy Vijay Amirtharaj

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Overview

In vitro and in vivo analysis shows comparable antibacterial effects of piper betle leaf extract and chlorhexidine, suggesting effective microbial control methods for high-caries risk patients.

Key Points

  • Piper betle leaf extract showed antibacterial activity similar to chlorhexidine, indicating potential as a natural mouth rinse alternative.
  • The minimum inhibitory concentration for piper betle extract was 500 μg/mL, while chlorhexidine was 250 μg/mL, revealing distinct efficacy levels.
  • Real-time PCR analysis showed reduced bacterial DNA copies after using both treatments, underscoring their effectiveness for high-caries risk individuals.
  • Salivary pH and buffering capacity improved with both piper betle and chlorhexidine, highlighting their role in oral health management.

Cite This Study

Justin et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d647791c5https://doi.org/10.4103/ajprhc.ajprhc_16_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative evaluation of antimicrobial effectiveness of 2% chlorhexidine, 25% aqueous extract of propolis, and 2.4% curcuma longa as intracanal irrigants: An ex vivo study2025
  2. 2Antibacterial and Antibiofilm Activity of TheraBreath™ Oral Rinses: An In Vitro Study2025
  3. 3Antimicrobial Effects of Aloe Vera Mouthwash in Adults with Dental Caries: A Preliminary Clinical Trial2025
  4. 4Investigating the role of Citrus sinensis, curcumin, and chlorhexidine mouthwashes as adjuncts to mechanical plaque control in the treatment of gingivitis: A randomized clinical study2025
  5. 5Effect of a Chlorhexidine Gluconate-Based Oral Rinse Containing Natural Bioflavonoids on Soft Tissue Inflammation and Subgingival Porphyromonas Gingivalis Carriage in Patients With Peri-Implant Mucositis.2025