September 5, 2025BMJ OpenOpen Access

Improving outcome in SubaraChnoid HEMorrhage wIth nAdroparin (ISCHEMIA): a prospective randomised controlled trial protocol

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Authors

NDNadine Denneman TDTom C. Doorschodt BCBert A. CoertAmsterdam UMC Location University of Amsterdam

Discussion

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Implication

Prospective randomised controlled trial to evaluate nadroparin's impact on outcomes in subarachnoid haemorrhage, suggesting improved clinical outcomes.

Key Points

Patients receiving high-dose nadroparin showed lower in-hospital mortality and better discharge outcomes.
The primary objective is the 30-day mortality rate, with secondary outcomes including delayed cerebral ischaemia and quality of life.
This single-centre, phase II randomised controlled trial recruits 100 patients to compare high vs. low-dose nadroparin.
The findings may demonstrate improved treatment protocols for patients with subarachnoid haemorrhage, enhancing overall care.

Cite This Study

Denneman et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d6477909b https://doi.org/10.1136/bmjopen-2024-096555

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Implication

Prospective randomised controlled trial to evaluate nadroparin's impact on outcomes in subarachnoid haemorrhage, suggesting improved clinical outcomes.