September 5, 2025Open Access

Blood pressure variability compromises vascular function in middle-aged mice

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Chronic blood pressure variability leads to impaired vascular function and cognitive deficits.
Mice with blood pressure variability showed a blunted bradycardic response and heightened myogenic response.
Intermittent Angiotensin II infusions were used to create the blood pressure variability model in middle-aged mice.
Findings emphasize the importance of blood pressure variability in understanding cognitive decline and brain health.

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Implication

Novel murine model reveals that blood pressure variability affects vascular function and cognitive outcomes, suggesting implications for brain health.

Cite This Study

Mendiola et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64778f7a https://doi.org/10.7554/elife.104082.2

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Implication

Novel murine model reveals that blood pressure variability affects vascular function and cognitive outcomes, suggesting implications for brain health.

Blood pressure variability compromises vascular function in middle-aged mice

Key Points

Discussion

Implication

Cite This Study

Blood pressure variability compromises vascular function in middle-aged mice

Key Points

Discussion

Implication

Cite This Study

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