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September 5, 2025JAMA Network OpenOpen Access

Sex-Related Differences in Non–Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation

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Authors

CCCorentin ChaumontAOAlireza OraiiOROriol Rodríguez-Queraltó

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Overview

Cohort study shows higher prevalence of non-PV triggers in women, indicating worse outcomes post-ablation.

Key Points

  • Women had a higher prevalence of non-PV triggers than men, with right atrial triggers being more common.
  • Among those with non-PV triggers identified, women experienced a higher 1-year atrial arrhythmia recurrence rate with a hazard ratio of 1.77.
  • The study noted that multiple non-PV triggers were more frequent in women compared to men.
  • Left atrial triggers did not show significant differences between sexes, highlighting a specific disparity in right atrial triggers.

Cite This Study

Chaumont et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64778f31https://doi.org/10.1001/jamanetworkopen.2025.29527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-Voltage areas in women with atrial fibrillation: Implications for tailored ablation strategies2026
  2. 2Identification of pulmonary vein triggers during de novo catheter ablation for atrial fibrillation predicts better clinical outcomes2026
  3. 3Mapping and ablation outcomes of extra-pulmonary vein triggers in atrial fibrillation: Single-center retrospective study with consistent provocation protocol.2025 · 3 citations
  4. 4Sex-based differences in bi-atrial structure, function, and electrophysiology in atrial fibrillation2026
  5. 5Sex-based procedural differences with the novel ballon in a basket pulsed field ablation catheter ( VOLT- PFA ) in atrial fibrillation (AF) ablation. Insight from italian experience2026