Gut Microbiota‐Bile Acid Metabolism Axis Drive Anti‐Diabetic Effects of Polygonatum cyrtonema Polysaccharide on Glycolipid Metabolism and Intestinal Inflammation
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Key Points
Polygonatum cyrtonema polysaccharide significantly improved blood glucose and lipids in type 2 diabetes mellitus rats, restoring metabolic balance.
The intervention led to increased levels of short-chain fatty acids and enhanced bile acid-converting microbiota, which contributed to its effectiveness.
Through a microbiota-bile acid crosstalk axis, PCP-80% activated key receptors improving glucose and lipid regulation in the studied model.
This study highlights the therapeutic potential of Polygonatum cyrtonema in managing metabolic disorders linked to intestinal inflammation.
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Implication
Multi-omics analysis shows that polysaccharide improves blood glucose and lipid levels in T2DM rats, suggesting a microbiota-bile acid interaction.